Championship side Barnsley produced one of the great FA Cup upsets when they beat Liverpool 2-1 at Anfield, but they will require something just as special if they are to force their way into the semi-final.
Manchester United, who beat Arsenal Saturday, are involved in the only all-Premier League tie as they face Portsmouth at home.
There is sure to be one non-Premier League side in the semi-final after League One Bristol Rovers, the lowest-ranked team still left in the competition, drew Championship side West Bromwich Albion
Sheffield United or Middlesbrough, who replay next Tuesday, have a home tie against Cardiff City.
The ties will be played over the weekend of the 8th and 9th of March.