Group F is one of the tightest groups with four clubs fighting for the three available places and only Red Star Belgrade out of the running.
German giants Bayern Munich welcome Aris Saloniki Wednesday needing a draw to qualify while victory would see Ottmar Hitzfeld's side finish top of the group.
SC Braga face Red Star needing to win by two clear goals or to win and score three times to move ahead of Bolton Wanderers, who don't play. However, if Bayern or Aris secure all the points in their match Bolton are guaranteed a place in the last 32.
The top three qualifying spots in Group E are already settled with Spartak Moscow, Zurich and Bayer Leverkusen all through. Spartak travel to Toulouse looking for a win to finish top of the group while Zurich welcome Leverkusen.
Tottenham Hotspur are already assured of qualification from Group G with Getafe, Anderlecht and Hapoel Tel Aviv fighting it out for the remaining two places.
A draw will be enough for Getafe against Anderlecht while Hapoel Tel Aviv need to win at home to Aalborg and hope Getafe win or are beaten by three goals.
With Bordeaux and Helsinborgs already through from Group H, Galatasaray and Panionios are the two teams in the running for the final qualifying spot. The Greeks play Bordeaux knowing a win will guarantee a top three finish while a draw against Austria Vienna could be enough for Galatasaray if Panionios go down against the French.
On Thursday, Everton play AZ Alkmaar safe in the knowledge that they will finish top of Group A regardless of the result while German Cup holders Nuremberg take on Larisa needing a win to be certain of booking their place in the next round.
Already qualified Panathinaikos and Atletico Madrid battle it out for the top spot in Group B while Scottish side Aberdeen can secure third place with a win at home to Copenhagen.
Only Villarreal are assured of qualifying from Group C ahead of their visit to AEK Athens. The Greeks need a win to be sure of qualifying while Fiorentina entertain Mlada Boleslav requiring only a draw.
SV Hamburg and Basle meet in Germany to see who finishes top of Group D. The Bundesliga side have won their three games to date and only need a draw.
The third qualifying place is currently occupied by Brann Bergen, who have played all their matches, but the Norwegians can still be pipped to qualification by either French side Stade Rennes or Dinamo Zagreb.
Both sides need to win by three goals to be sure of qualifying ahead of Bergen.
The 24 qualifiers will be joined by eight third-placed teams in the group phase of the Champions League for the round of 32, a knock-out stage over two legs, with first games to be played on February 13 and 14.