During a press conference on Monday, he explained that he would be hosting a new show on ModerNine and that due to a timing conflict, it would be impossible for him to do both.
"There's no need to be sad. No one has died," he joked, bringing a smile to the faces of his fans and the programme's team.
"I'm sure to see you all but I have to leave because the organisation (producer JSL Co) and I have to face up to the changes.
"But I can assure that my feelings - the love I feel for the show - are the same as when I began 17 years ago."
Sanya's co-host Piti Bhirombhakdi has also decided to call it quits to allow the producers to come up with a brand new duo to host the show.