
Depp joined "Pirates of the Caribbean: Dead Man's Chest" producer Jerry Bruckheimer to accept the Golden Popcorn trophy.
"This is the man who did it all right here, Johnny Depp," Bruckheimer said. "Without him, we wouldn't be here."
"I'd like to thank this man and Disney for not firing me first," Depp quipped.
Other big winners during the live broadcast from the Gibson Amphitheater included Mike Myers, who won the MTV Generation Award, and Sacha Baron Cohen, who collected two trophies.
Cohen earned the comedic performance prize for his starring turn in "Borat: Cultural Learnings of America for Make Benefit Glorious Nation of Kazakhstan."
"Unfortunately, Borat can't be here tonight," he joked. "He's been feeling the pressures of fame and had to check himself into rehab."